ACADEMIC RESEARCH • ಾ⻐研 2019 UMAGAZINE 20 • 澳大ᑓゆ 60 澳㟓́ ⟰#3$"⑪ㅌṸᦷ 澳㟑ᕔ 0૦⭤̿ ۲䢬 0䢥͞ ˔ᒴଛ လ䢬9 䢥ᒴ͞ ༴ᖣ᳤̿ ˷ⅰ中२̿ ǎ̒ ⥎⅂ᒴ澳㟑ଛလᆳᕔ⅂⃛ 㧙় 中ᕍຯ發 ⅰ⅂⃛ 䢬ॺ200 ⦮201 㟠澳㟑 Ս〹ᑘ֦ 1 ϟ̒ ⥎⅂⃚ ϟǎᆒмഭ 澳㟑̿ ⟮㐫⻋̜ 研͞ ≋⿼澳㟑̿ ⟮中 #3$"् ⅰ⑨ㅊṶᦵǎ㐜㐿ഭ2 000 ܓ 澳㟑個㭓ⅰ֯ ᖾ䢬ᆒмഊ澳㟑̿ ⟮中#3$"⑨ㅊ㧀ἐᒛ㧧㭗ᑜՐ͒̿ ⟮䢬㐛ዞ⍵#3$"⑨ㅊഭ澳㟑ଛလ̒ ⥎ ⅂ⅰε ۽ 能㭗ᑜՐ͒̿ ⟮䢨९ˍ䢩ǎ Ϛ⦨澳㟑̿ ⟮#3$"⑨ㅊᐨᎭⅰˍ個㕳 ⾾လॺᑜೇ ۽ ↽ᅞᑜٛ ሱ༴ᖣ䢬㩿 ݶ 澳㟑ঁ چ ॺՅⅰ◼澳大Ტ چ 1ӹ̿ ⟮ⅰ⅂⃛ 㦞㠴中ǎ大Ტ ⟮ ̿چ ൰ᑜ ̿ڗ ⟮䢬ᒴ中२̿ ⟮ⅰˍ個֯ Ᏻ䢬Ր㑤ҵ ⣌ᓡ⦾中२Յঁ̿ ⟮ᕔྩ 大˗ ܒ ǎⁱᑜ 澳㟑̿ ⟮⦾◼澳大Ტ چ ⅰ̿ ⟮㑤ҵ⣌ ᓡⅰˍ⦯လ䢬澳㟑̿ ⟮᳤ 研◼澳大 Ტ ⟮ ̿چ ⅰ#3$"⑨ㅊዞϫ̜ ˍ個⨏ତ ⅰឹ ḙ䢬⡈澳㟑̿ ⟮中發έⅰᑪḿ₠ လ#3$"⑨ㅊ ͞۽ ↽ᑜᐤ個◼澳 大Ტ چ ⅰ⅂⃛ 㦞㠴 ݶ ℼǎᆒмᢩ ॺᕥ 㐛個ᑚ ؛ؤܗ 中䢬ٛ ሱᏃ大ഭ澳㟑̿ ⟮ ᫎ╈४䢬˧ॺ༴ᖣ̿ ⟮中㐫⻋大⿈ឹ 㬟ㄕε䢬᳤ 㐫ˍॺ◼澳大Ტ چ BRCA Mutations in Macao We further analysed BRCA mutations in Macao. Macao has a population of over 600,000, in which over 50 per cent are female, and 95 per cent are of Chinese ethnicity and predominantly Cantonese. Breast cancer is the most commonly occurring cancer of all cancer types in females in Macao, with 1,353 breast cancer cases diagnosed between 2003 and 2013. Through analysing 2,000 individuals in Macao, we observed a higher frequency of BRCA mutations in the Macao population than in other populations. This suggests that BRCA mutations can play a more significant role in breast cancer in the Macao population than in other populations (Fig.1). A significance of studying the population in Macao is that the data can be readily applicable to the population in the Greater Bay Area, including Guangdong, Hong Kong, and Macao. The population in the Greater Bay Area is a subgroup of the Chinese population known as Lingnan, whose genetic background is known to be substantially different from that of the inland Chinese population. As Macao’s population is genetically the same as people in the Greater Bay Area, the ethnic-specific BRCA mutation identified in the Macao population should be the same as the population in the Greater Bay Area. Therefore, Macao’s population provides a perfect model to study BRCA mutation in the population of the Greater Bay Area, and the BRCA mutations identified in the Macao population are readily applicable for cancer ἔ൴㲊ᐑእⅰ研॰㡴 The research team of Prof Wang Shanming
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