ἔ൴㲊䢬澳㟑大ಾҀ༏⏲ಾಾ㡕ᐑእ䢬↷ נ 研㕳㷞᳤ 㐼㕕ಾ㑤ҵಾǍ् ♲ಾ ݶ ḳ㇒〙ಾ ⅰᑚᧈύ⿼㑤ҵ् ♖ॺ⅂⃛ 發˔ⅰε䢬 ݶ 發ൠॺ⟮㭓൪㤘㦞㠴㑤ҵ⑨ㅊᆳ⦯⅂⃛ ⅰ┆ₗǎ Wang Shanming is a professor in the Faculty of Health Sciences, University of Macau. His current research focuses on the use of medical genetics, genomics, and bioinformatics methods to understand the role of genetic factors in cancer development, and the development of strategies to prevent cancer caused by genetic mutations at the population level. ಾ⻐研 • ACADEMIC RESEARCH 澳大ᑓゆ • 2019 UMAGAZINE 20 61 prevention and treatment in the entire area inhabited by a population of over 100 million, in which systematic investigations into BRCA mutations have been very limited. We are working hard in this direction, including expanding the coverage of testing in the Macao population and conducting large-scale verification work in the Guangdong population. Our work should lay a solid foundation for cancer prevention through promoting BRCA gene mutation screening for the population in the Greater Bay Area. Note: This is the first large open-access Chinese BRCA mutation database, which contains data on almost all known BRCA mutations found in the Chinese population. This is also one of the largest non-Caucasian single-country BRCA mutation databases. It is the hope of the Faculty of Health Sciences that this database will promote the study of BRCA-related cancers in the Chinese population and the clinical applications of the research results, and enhance domestic and international collaboration in the field. ९ˍ ğ 澳㟑̿ ⟮#3$"ᐨᎭⅰḿ㷞۠ Րഭ大Ტ ⟮ ̿چ ⅰ⟳䢺९᳤ 㤔中२̿ ⟮Ǎ中२̿ ⟮ ݶ 中२澳㟑̿ ⟮́ 㟠#3$"⑨ㅊᐨᎭⅰ㍦䢬♺ ᗈ᪷ ⻠ᒛॺ˗ ⟮ ̿ܒ 中#3$"⑨ㅊಥॺ㧧⮍ⅰ₠䢬⡈˜澳㟑̿ ⟮ՑᕔՐḿ₠လ䢻܁९᳤ 大Ტ ঁچ ९䢬ⁱᑜ大Ტ ⟮ ̿چ Ցᕔ㧙Θⅰ㑤ҵ⣌ ᓡ䢬澳㟑̿ ⟮ ͞۽ ε᳤ 大Ტ ⟮ ̿چ ⅂⃛ 㦞㠴Ǎ〹ᑘ ݶ ℼ研ⅰύႰឹ ḙ䢨大Ტ ঁچ ९ᬚ⦨⛆⚈䢩ǎ Figure 1 ğ The characteristics of the BRCA data on the Macao population and the implications for the Greater Bay Area: Diagram on the left is a comparison of BRCA data on non-Chinese populations, Chinese population, and Macao population. It clearly shows that BRCA mutations in humans are highly ethnic-specific and differ significantly across different populations. Diagram on the right is a map of the Greater Bay Area (Internet photo). As the Macao population is genetically the same as the population in the Greater Bay Area, Macao provides a perfect model to study BRCA mutation in the population of the Greater Bay Area, and the BRCA mutations identified in the Macao population are readily applicable for cancer prevention and treatment in the entire region. ༴㐜㐿大⿈ឹ̿ ⟮#3$"् ⑨ㅊ╥ ᗾ㐫⻋⅂⃛ 㦞㠴ˍ個ਖⅰ⍓ǎ 〺䢺ᕲᐨᎭ༄᳤ ⓥˍ個大⿈ឹ ǍՊ↞လǍ㟘 Ս̷ ⅰ中२̿ ⟮#3$"ㅊ₠ᐨᎭ༄䢬ि ሱ̜ ̃ ᆳᕔ↷ נ ຂ≷ⅰϚ⦨ᑜ中२̿ ⟮ⅰ #3$"ㅊ₠ᐨᎭǎᕲᐨᎭ༄̏ ᒴϚ⦨㤔㭗؝ ♘̿ ⟮ ࡘ ˍ२೮ⅰᕍ大#3$"ㅊ₠ᐨᎭ༄́ ˍǎҀ༏⏲ಾಾ㡕ຒᕤᕲᐨᎭ༄ⅰཅ⒢ ݶ 㟘 ധЂ㐫中२̿ ⟮#3$"⇀㠙⅂⃛ ⅰ研 ݶ ⦦ᅞ䢬˧ ػ २Յ ݶ २㢂㟠ॺᢪ㦦৴ⅰ εǎ
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