COVER STORY•封面專題 2020 UMAGAZINE 22•澳大新語 14 癌細胞在飢餓情況下激活自噬 Cancer cells undergoing autophagy induced by starvation Caveolin-1 (CAV1) is an important tumour suppressor in breast cancer. Its deficiency and mutation can affect the autophagy and lysosome, thus making breast cancer cells more susceptible to autophagy/lysosome inhibitors. Faculty of Health Sciences Professor Shen Hanming suggests that CAV1’s deficiency and mutation can be used as a biomarker in the selection of breast cancer patients for using autophagy/lysosome inhibitors in cancer therapy. Caveolin-1（CAV1）是一種乳腺癌抑制基因，人體缺少了它或它發生突變時，就 會影響癌細胞的自噬作用和溶酶體功能，增加患上乳腺癌的風險。健康科學學院 教授沈漢明發現，可以用CAV1的缺失或突變作為生物指標，指導在臨床上是否適 合用自噬抑制劑作為治療乳腺癌的手段。 用細胞自噬抑制劑治療乳腺癌 Treating Breast Cancer with Autophagy Inhibitors 文/盛惠怡‧圖/編輯部，部分由受訪者提供 Chinese & English Text / Debby Seng ‧ Photo / Editorial Board with some provided by the interviewee
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